Case Report The Case of a Melting Face: Parry–Romberg Syndrome: Progressive Hemifacial Atrophy
Authors
Dr.Shamisha Khade, Dr.Jharna Mahajan(Bhanushali), Dr.Satish KhadilkarFiles
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Journal
Published in Vol. 68 No. 1 (2026) of Bombay Hospital Journal.
Bombay Hospital Journal (BHJ) is a peer-reviewed quarterly published Print and Online journal. It is an official Journal of Bombay Hospital institute of medical sciences. The aim of BHJ is to improve medical care by publishing sound scientific articles (both research and practice papers) and focusing on topics that are of great importance to its readership.
Editor-in-Chief- Dr Satish Vasant Khadilkar
About the JournalAbstract
Background: Parry–Romberg syndrome (PRS), or progressive hemifacial atrophy, is a rare acquired disorder characterized by unilateral facial tissue loss of uncertain etiology. It is often associated with neurological, ocular, dental, and autoimmune manifestations.
Case Report: We report a 38-year-old woman with 12–13 years of progressive right-sided facial atrophy associated with enophthalmos and hypothyroidism. Clinical examination showed marked hemifacial atrophy involving skin, soft tissue, and jaw with no neurological deficits.
Conclusion: This case highlights the classical presentation of PRS with ocular involvement and autoimmune association. Early recognition and multidisciplinary management are essential to optimize functional and cosmetic outcomes.
Keywords: Parry–Romberg syndrome, progressive hemifacial atrophy, enophthalmos, hypothyroidism, autoimmune
References
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Tolkachjov SN, Patel NG, Tollefson MM. Progressive hemifacial atrophy: a review. Orphanet J Rare Dis. 2015;10:39.
Yu J, Zhang Y, Li X, et al. Genetic variations in patients with Parry-Romberg syndrome. Sci Rep. 2023;13:11245.
Jaykar R, Patil S, Deshmukh A. Parry-Romberg syndrome associated with hypothyroidism. Indian J Postgrad Dermatol. 2025;6(2):85–88.
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© The Author(s). 2024 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.
